Curcumin has Curative Effect on Isoniazid-Rifampicin Induced Hepatotoxicity

Background: Anti-tuberculosis drugs-induced hepatotoxicity is associated with oxidative stress. Curcumin a powerful antioxidant and has been found to protect the liver from damaging effects of The study aimed assess curative protective against induced by anti TB- drugs (Isoniazid-Rifampicin) using an experimental model Albino rabbits. Methods: rabbits(n=24) were divided into four groups. Group A was control group, B administered Isoniazid (INH) (50 mg/kg/d) Rifampicin (RMP) (100 mg/kg) alone, C received both INH+RMP (60 before during induction. D INH RMP for 7 days, followed days mg/kg/d). Biochemical testing morphological histopathology done all All values recorded in mean ± standard deviation. Results: Anti-Tuberculosis increased Alanine Transaminase (ALT), Aspartate level (AST), Alkaline Phosphatase (ALP), Total Bilirubin, Albumin 62.0±2.5, 172.5±1.0, 128±1.5, 0.80±0.05, 5.00±0.5 respectively decreased protein levels (2.05±1.0). Whereas, lowered enzymes 37.0±2.8, 126.12±1.5, 90.5±1.0, 0.40±0.01, 3.50±0.5 respectively, total (5.00±0.5). exhibited normal morphology, whereas, had ballooning degeneration, focal cell necrosis, inflammation. moderate fatty but no centrilobular degeneration or necrosis minor inflammation morphology. Conclusion: preventative therapeutic remedy which can be used treatment hepatotoxicity. Keywords: Curcumin; Hepatotoxicity; Hepatoprotective; Isoniazid; Rifampicin.